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atrial cardiomyocytes  (Axol Bioscience)
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Axol Bioscience atrial cardiomyocytes
Inositol trisphosphate (IP 3 ) pathway is active in human atrial induced pluripotent stem cells (iPSCs) as shown using multielectrode array. A : representative averaged multielectrode array (MEA) field action potential waveforms from control (dimethylsulfoxide, DMSO; n = 7), phenylephrine (PE; 30 μM; n = 11), and PE (1 or 30 μM) in the presence of either H89 (1 μM; n = 7) or MDL-12330A (3 μM; n = 1–10). B : effect of H89 (1 μM) and MDL-12330A (3 μM) on the beat rate of human iPSCs-derived atrial <t>cardiomyocytes</t> (hiPSC-ACMs) in response to PE at concentrations of 1–30 μM (DMSO, n = 7; H89, n = 7; MDL-12330A, n = 10). Data are represented as means ± SD. * P < 0.05, ** P < 0.01, and *** P < 0.001, 2-way repeated-measures ANOVA followed by Sidak’s multiple comparisons. IP 3 , inositol (1,4,5)-trisphosphate.
Atrial Cardiomyocytes, supplied by Axol Bioscience, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Inositol trisphosphate (IP 3 ) pathway is active in human atrial induced pluripotent stem cells (iPSCs) as shown using multielectrode array. A : representative averaged multielectrode array (MEA) field action potential waveforms from control (dimethylsulfoxide, DMSO; n = 7), phenylephrine (PE; 30 μM; n = 11), and PE (1 or 30 μM) in the presence of either H89 (1 μM; n = 7) or MDL-12330A (3 μM; n = 1–10). B : effect of H89 (1 μM) and MDL-12330A (3 μM) on the beat rate of human iPSCs-derived atrial cardiomyocytes (hiPSC-ACMs) in response to PE at concentrations of 1–30 μM (DMSO, n = 7; H89, n = 7; MDL-12330A, n = 10). Data are represented as means ± SD. * P < 0.05, ** P < 0.01, and *** P < 0.001, 2-way repeated-measures ANOVA followed by Sidak’s multiple comparisons. IP 3 , inositol (1,4,5)-trisphosphate.

Journal: American Journal of Physiology - Heart and Circulatory Physiology

Article Title: Activation of IP 3 R in atrial cardiomyocytes leads to generation of cytosolic cAMP

doi: 10.1152/ajpheart.00152.2024

Figure Lengend Snippet: Inositol trisphosphate (IP 3 ) pathway is active in human atrial induced pluripotent stem cells (iPSCs) as shown using multielectrode array. A : representative averaged multielectrode array (MEA) field action potential waveforms from control (dimethylsulfoxide, DMSO; n = 7), phenylephrine (PE; 30 μM; n = 11), and PE (1 or 30 μM) in the presence of either H89 (1 μM; n = 7) or MDL-12330A (3 μM; n = 1–10). B : effect of H89 (1 μM) and MDL-12330A (3 μM) on the beat rate of human iPSCs-derived atrial cardiomyocytes (hiPSC-ACMs) in response to PE at concentrations of 1–30 μM (DMSO, n = 7; H89, n = 7; MDL-12330A, n = 10). Data are represented as means ± SD. * P < 0.05, ** P < 0.01, and *** P < 0.001, 2-way repeated-measures ANOVA followed by Sidak’s multiple comparisons. IP 3 , inositol (1,4,5)-trisphosphate.

Article Snippet: For multielectrode array (MEA) experiments, human induced pluripotent stem cells-derived atrial cardiomyocytes (hiPSC-ACMs) (ax2518, Axol Bioscience, UK) were cultured at 5.0 × 10 5 cells/well on a 768-channel 48-well Axion Cytoview MEA 48 plate (M768-tMEA-48B, Axion Biosystems, USA) coated with Axol’s Fibronectin Coating Solution (ax0049, Axol Bioscience, UK) at 37°C in a 5% CO 2 –95% air atmosphere.

Techniques: Control, Derivative Assay